Association of angiotensin II type-1 receptor A1166C gene polymorphism with the susceptibility of immunoglobulin A nephropathy.

ABSTRACT

Association of angiotensin II type-1 receptor (AT1R) A1166C gene polymorphism with the susceptibility of immunoglobulin A nephropathy (IgAN) is still controversial. This meta-analysis was conducted to evaluate the association of AT1R A1166C gene polymorphism with IgAN susceptibility. The search was performed in the databases of PubMed, Embase, and Cochrane Library as of 1 May 2014. The eligible investigations were recruited for this meta-analysis. Four literatures on the association between AT1R A1166C gene polymorphism and IgAN susceptibility were identified for this meta-analysis. Interestingly, all the included studies were from Asian population. There was no association between AT1R A1166C gene polymorphism and IgAN susceptibility for overall populations (C allele vs. A allele OR = 1.04, 95% CI 0.78-1.39, p = 0.76; CC vs. AC + AA OR = 1.20, 95% CI 0.48-2.98, p = 0.70; AA vs. AC + CC OR = 0.97, 95% CI 0.70-1.34, p = 0.85), and in Asians. In conclusion, AT1R A1166C gene polymorphism was not associated with IgAN susceptibility in Asian population. However, more case-control association investigations on larger, stratified populations are required in the future.