The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPAR&#945;-cyclophilin D interaction in cardiomyocytes.

Barreto-Torres, Giselle; Hernandez, Jessica Soto; Jang, Sehwan; Rodríguez-Muñoz, Adlín R; Torres-Ramos, Carlos A; Basnakian, Alexei G; Javadov, Sabzali

The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPARα-cyclophilin D interaction in cardiomyocytes.

Barreto-Torres, Giselle; Hernandez, Jessica Soto; Jang, Sehwan; Rodríguez-Muñoz, Adlín R; Torres-Ramos, Carlos A; Basnakian, Alexei G; Javadov, Sabzali.

Affiliation

Barreto-Torres G; Department of Physiology, School of Medicine, University of Puerto Rico, San Juan, Puerto Rico; and.
Hernandez JS; Department of Physiology, School of Medicine, University of Puerto Rico, San Juan, Puerto Rico; and.
Jang S; Department of Physiology, School of Medicine, University of Puerto Rico, San Juan, Puerto Rico; and.
Rodríguez-Muñoz AR; Department of Physiology, School of Medicine, University of Puerto Rico, San Juan, Puerto Rico; and.
Torres-Ramos CA; Department of Physiology, School of Medicine, University of Puerto Rico, San Juan, Puerto Rico; and.
Basnakian AG; Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Javadov S; Department of Physiology, School of Medicine, University of Puerto Rico, San Juan, Puerto Rico; and sabzali.javadov@upr.edu.

Am J Physiol Heart Circ Physiol ; 308(7): H749-58, 2015 Apr 01.

Article in En | MEDLINE | ID: mdl-25617357

Subject(s)

Adenylate Kinase/metabolism; Antioxidants/pharmacology; Cyclophilins/metabolism; Enzyme Activators/pharmacology; Metformin/pharmacology; Myocytes, Cardiac/drug effects; Oxidative Stress/drug effects; PPAR alpha/metabolism; Adenylate Kinase/antagonists & inhibitors; Animals; Biphenyl Compounds; Cell Death/drug effects; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Membrane Potential, Mitochondrial/drug effects; Mitochondria, Heart/drug effects; Mitochondria, Heart/enzymology; Mitochondrial Membrane Transport Proteins/metabolism; Mitochondrial Permeability Transition Pore; Myocytes, Cardiac/enzymology; Myocytes, Cardiac/pathology; Oxidants/pharmacology; PPAR alpha/antagonists & inhibitors; Protein Binding; Protein Kinase Inhibitors/pharmacology; Pyrones/pharmacology; Rats; Reactive Oxygen Species/metabolism; Signal Transduction/drug effects; Thiophenes/pharmacology

Key words

AMPK; H9c2 cardiomyocytes; PPARα; metformin; mitochondria; oxidative stress

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adenylate Kinase / Oxidative Stress / Enzyme Activators / Cyclophilins / Myocytes, Cardiac / PPAR alpha / Metformin / Antioxidants Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Am J Physiol Heart Circ Physiol Journal subject: CARDIOLOGIA / FISIOLOGIA Year: 2015 Document type: Article

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