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The lipid peroxidation product 4-hydroxy-trans-2-nonenal causes protein synthesis in cardiac myocytes via activated mTORC1-p70S6K-RPS6 signaling.
Calamaras, Timothy D; Lee, Charlie; Lan, Fan; Ido, Yasuo; Siwik, Deborah A; Colucci, Wilson S.
Affiliation
  • Calamaras TD; Myocardial Biology Unit, Cardiovascular Medicine, and Diabetes and Metabolism Research Unit, Section of Endocrinology, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
  • Lee C; Brigham and Women׳s Hospital, Boston, MA 02115, USA.
  • Lan F; Department of Endocrinology, Second Affiliated Hospital Chongqing Medical University, Chongqing, China.
  • Ido Y; Diabetes and Metabolism Research Unit, Section of Endocrinology, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
  • Siwik DA; Myocardial Biology Unit, Cardiovascular Medicine, and Diabetes and Metabolism Research Unit, Section of Endocrinology, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
  • Colucci WS; Myocardial Biology Unit, Cardiovascular Medicine, and Diabetes and Metabolism Research Unit, Section of Endocrinology, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA. Electronic address: Wilson.colucci@bmc.org.
Free Radic Biol Med ; 82: 137-46, 2015 May.
Article in En | MEDLINE | ID: mdl-25617592
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lipid Peroxidation / Myocytes, Cardiac / Ribosomal Protein S6 Kinases, 70-kDa / Ribosomal Protein S6 / Multiprotein Complexes / Aldehydes / TOR Serine-Threonine Kinases Type of study: Etiology_studies Limits: Animals Language: En Journal: Free Radic Biol Med Journal subject: BIOQUIMICA / MEDICINA Year: 2015 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lipid Peroxidation / Myocytes, Cardiac / Ribosomal Protein S6 Kinases, 70-kDa / Ribosomal Protein S6 / Multiprotein Complexes / Aldehydes / TOR Serine-Threonine Kinases Type of study: Etiology_studies Limits: Animals Language: En Journal: Free Radic Biol Med Journal subject: BIOQUIMICA / MEDICINA Year: 2015 Document type: Article Affiliation country: United States