Discovery of antibiotic (E)-3-(3-carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one.

Bouley, Renee; Kumarasiri, Malika; Peng, Zhihong; Otero, Lisandro H; Song, Wei; Suckow, Mark A; Schroeder, Valerie A; Wolter, William R; Lastochkin, Elena; Antunes, Nuno T; Pi, Hualiang; Vakulenko, Sergei; Hermoso, Juan A; Chang, Mayland; Mobashery, Shahriar

Bouley, Renee; Kumarasiri, Malika; Peng, Zhihong; Otero, Lisandro H; Song, Wei; Suckow, Mark A; Schroeder, Valerie A; Wolter, William R; Lastochkin, Elena; Antunes, Nuno T; Pi, Hualiang; Vakulenko, Sergei; Hermoso, Juan A; Chang, Mayland; Mobashery, Shahriar.

Affiliation

Bouley R; Department of Chemistry and Biochemistry, University of Notre Dame , Notre Dame, Indiana 46556, United States.

J Am Chem Soc ; 137(5): 1738-41, 2015 Feb 11.

Article in En | MEDLINE | ID: mdl-25629446

Subject(s)

Anti-Bacterial Agents/pharmacology; Drug Discovery; Quinazolinones/pharmacology; Anti-Bacterial Agents/pharmacokinetics; Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Biological Availability; Microbial Sensitivity Tests; Models, Molecular; Penicillin-Binding Proteins; Protein Conformation; Quinazolinones/pharmacokinetics; Staphylococcus/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinazolinones / Drug Discovery / Anti-Bacterial Agents Language: En Journal: J Am Chem Soc Year: 2015 Document type: Article Affiliation country: United States Country of publication: United States

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