Sirtuin 1 is a negative regulator of parathyroid hormone stimulation of matrix metalloproteinase 13 expression in osteoblastic cells: role of sirtuin 1 in the action of PTH on osteoblasts.

Fei, Yurong; Shimizu, Emi; McBurney, Michael W; Partridge, Nicola C

Fei, Yurong; Shimizu, Emi; McBurney, Michael W; Partridge, Nicola C.

Affiliation

Fei Y; From the Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York 10010 and.
Shimizu E; From the Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York 10010 and.
McBurney MW; the Ottawa Health Research Center Institute, Ottawa, Ontario K1H 8L6, Canada.
Partridge NC; From the Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York 10010 and ncp234@nyu.edu.

J Biol Chem ; 290(13): 8373-82, 2015 Mar 27.

Article in En | MEDLINE | ID: mdl-25631045

Subject(s)

Matrix Metalloproteinase 13/metabolism; Osteoblasts/enzymology; Parathyroid Hormone/physiology; Sirtuin 1/physiology; Acetylation; Animals; Binding Sites; Enzyme Induction; Female; Femur/cytology; Femur/enzymology; Gene Expression; Male; Matrix Metalloproteinase 13/genetics; Mice, Inbred C57BL; Mice, Knockout; Promoter Regions, Genetic; Protein Binding; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-jun/metabolism; Transcription Factor AP-1/metabolism

Key words

AP1 Transcription Factor (AP-1); Matrix Metalloproteinase (MMP); Osteoblast; PTH; Parathyroid Hormone; Sirtuin 1 (SIRT1)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoblasts / Parathyroid Hormone / Matrix Metalloproteinase 13 / Sirtuin 1 Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Biol Chem Year: 2015 Document type: Article

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