Protection from noise-induced hearing loss with Src inhibitors.
Drug Discov Today
; 20(6): 760-5, 2015 Jun.
Article
in En
| MEDLINE
| ID: mdl-25637168
ABSTRACT
Noise-induced hearing loss is a major cause of acquired hearing loss around the world and pharmacological approaches to protecting the ear from noise are under investigation. Noise results in a combination of mechanical and metabolic damage pathways in the cochlea. The Src family of protein tyrosine kinases could be active in both pathways and Src inhibitors have successfully prevented noise-induced cochlear damage and hearing loss in animal models. The long-term goal is to optimize delivery methods into the cochlea to reduce invasiveness and limit side-effects before human clinical testing can be considered. At their current early stage of research investigation, Src inhibitors represent an exciting class of compounds for inclusion in a multifaceted pharmacological approach to protecting the ear from noise.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cochlea
/
Src-Family Kinases
/
Protein Kinase Inhibitors
/
Hearing Loss, Noise-Induced
Limits:
Animals
/
Humans
Language:
En
Journal:
Drug Discov Today
Journal subject:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Year:
2015
Document type:
Article