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Blockade of specific NOTCH ligands: a new promising approach in cancer therapy.
Briot, Anaïs; Iruela-Arispe, M Luisa.
Affiliation
  • Briot A; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California.
  • Iruela-Arispe ML; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California. Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California. Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California. arispe@mcdb.ucla.edu.
Cancer Discov ; 5(2): 112-4, 2015 Feb.
Article in En | MEDLINE | ID: mdl-25656896
ABSTRACT

SUMMARY:

The signaling specificity conveyed by distinct combination of NOTCH receptors/ligands has remained elusive. In this issue of Cancer Discovery, through the development of ligand-specific NOTCH inhibitors, Kangsamaksin and colleagues uncovered unique signaling outcomes downstream of DLL- and JAG-receptor activation and demonstrated their effects in the suppression of tumor angiogenesis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Fusion Proteins / Immunoglobulin Fc Fragments / Intercellular Signaling Peptides and Proteins / Receptors, Notch / Receptor, Notch1 / Neoplasms Limits: Animals / Female / Humans Language: En Journal: Cancer Discov Year: 2015 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Fusion Proteins / Immunoglobulin Fc Fragments / Intercellular Signaling Peptides and Proteins / Receptors, Notch / Receptor, Notch1 / Neoplasms Limits: Animals / Female / Humans Language: En Journal: Cancer Discov Year: 2015 Document type: Article