Quantitative assessments of the distinct contributions of polypeptide backbone amides versus side chain groups to chain expansion via chemical denaturation.

Holehouse, Alex S; Garai, Kanchan; Lyle, Nicholas; Vitalis, Andreas; Pappu, Rohit V

Holehouse, Alex S; Garai, Kanchan; Lyle, Nicholas; Vitalis, Andreas; Pappu, Rohit V.

Affiliation

Holehouse AS; Department of Biomedical Engineering and Center for Biological Systems Engineering, Washington University in St. Louis , One Brookings Drive, Campus Box 1097, St. Louis, Missouri 63130, United States.

J Am Chem Soc ; 137(8): 2984-95, 2015 Mar 04.

Article in En | MEDLINE | ID: mdl-25664638

Subject(s)

Amides/chemistry; Peptides/chemistry; Protein Denaturation/drug effects; Amino Acid Sequence; Dose-Response Relationship, Drug; Guanidine/pharmacology; Hydrophobic and Hydrophilic Interactions; Molecular Dynamics Simulation; Molecular Sequence Data; Protein Structure, Secondary; Urea/pharmacology; Water/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Protein Denaturation / Amides Language: En Journal: J Am Chem Soc Year: 2015 Document type: Article Affiliation country: United States Country of publication: United States

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