Your browser doesn't support javascript.
loading
The genomic and phenotypic diversity of Schizosaccharomyces pombe.
Jeffares, Daniel C; Rallis, Charalampos; Rieux, Adrien; Speed, Doug; Prevorovský, Martin; Mourier, Tobias; Marsellach, Francesc X; Iqbal, Zamin; Lau, Winston; Cheng, Tammy M K; Pracana, Rodrigo; Mülleder, Michael; Lawson, Jonathan L D; Chessel, Anatole; Bala, Sendu; Hellenthal, Garrett; O'Fallon, Brendan; Keane, Thomas; Simpson, Jared T; Bischof, Leanne; Tomiczek, Bartlomiej; Bitton, Danny A; Sideri, Theodora; Codlin, Sandra; Hellberg, Josephine E E U; van Trigt, Laurent; Jeffery, Linda; Li, Juan-Juan; Atkinson, Sophie; Thodberg, Malte; Febrer, Melanie; McLay, Kirsten; Drou, Nizar; Brown, William; Hayles, Jacqueline; Carazo Salas, Rafael E; Ralser, Markus; Maniatis, Nikolas; Balding, David J; Balloux, Francois; Durbin, Richard; Bähler, Jürg.
Affiliation
  • Jeffares DC; Department of Genetics, Evolution and Environment, University College London, London, UK.
  • Rallis C; Department of Genetics, Evolution and Environment, University College London, London, UK.
  • Rieux A; 1] Department of Genetics, Evolution and Environment, University College London, London, UK. [2] University College London Genetics Institute, University College London, London, UK.
  • Speed D; 1] Department of Genetics, Evolution and Environment, University College London, London, UK. [2] University College London Genetics Institute, University College London, London, UK.
  • Prevorovský M; Department of Cell Biology, Faculty of Science, Charles University in Prague, Prague, Czech Republic.
  • Mourier T; Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark.
  • Marsellach FX; Department of Genetics, Evolution and Environment, University College London, London, UK.
  • Iqbal Z; Wellcome Trust Centre for Human Genetics, Oxford, UK.
  • Lau W; Department of Genetics, Evolution and Environment, University College London, London, UK.
  • Cheng TM; Cell Cycle Laboratory, Cancer Research UK London Research Institute, London, UK.
  • Pracana R; Department of Genetics, Evolution and Environment, University College London, London, UK.
  • Mülleder M; Department of Biochemistry, University of Cambridge, Cambridge, UK.
  • Lawson JL; 1] Department of Genetics, University of Cambridge, Cambridge, UK. [2] Gurdon Institute, University of Cambridge, Cambridge, UK.
  • Chessel A; Department of Biochemistry, University of Cambridge, Cambridge, UK.
  • Bala S; Wellcome Trust Sanger Institute, Cambridge, UK.
  • Hellenthal G; 1] Department of Genetics, Evolution and Environment, University College London, London, UK. [2] University College London Genetics Institute, University College London, London, UK.
  • O'Fallon B; Associated Regional and University Pathologists, Inc. University of Utah, Salt Lake City, Utah, USA.
  • Keane T; Wellcome Trust Sanger Institute, Cambridge, UK.
  • Simpson JT; Wellcome Trust Sanger Institute, Cambridge, UK.
  • Bischof L; Commonwealth Scientific and Industrial Research Organisation (CSIRO) Mathematics, Informatics and Statistics, North Ryde, New South Wales, Australia.
  • Tomiczek B; Department of Genetics, Evolution and Environment, University College London, London, UK.
  • Bitton DA; Department of Genetics, Evolution and Environment, University College London, London, UK.
  • Sideri T; Department of Genetics, Evolution and Environment, University College London, London, UK.
  • Codlin S; Department of Genetics, Evolution and Environment, University College London, London, UK.
  • Hellberg JE; Department of Genetics, Evolution and Environment, University College London, London, UK.
  • van Trigt L; Department of Genetics, Evolution and Environment, University College London, London, UK.
  • Jeffery L; Cell Cycle Laboratory, Cancer Research UK London Research Institute, London, UK.
  • Li JJ; Cell Cycle Laboratory, Cancer Research UK London Research Institute, London, UK.
  • Atkinson S; Department of Genetics, Evolution and Environment, University College London, London, UK.
  • Thodberg M; Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark.
  • Febrer M; Genome Analysis Centre, Norwich, UK.
  • McLay K; Genome Analysis Centre, Norwich, UK.
  • Drou N; Genome Analysis Centre, Norwich, UK.
  • Brown W; Centre for Genetics and Genomics, University of Nottingham, Nottingham, UK.
  • Hayles J; Cell Cycle Laboratory, Cancer Research UK London Research Institute, London, UK.
  • Carazo Salas RE; 1] Department of Genetics, University of Cambridge, Cambridge, UK. [2] Gurdon Institute, University of Cambridge, Cambridge, UK.
  • Ralser M; 1] Department of Biochemistry, University of Cambridge, Cambridge, UK. [2] Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK. [3] Division of Physiology and Metabolism, Medical Research Council (MRC) National Institute for Medical Research, London, UK.
  • Maniatis N; Department of Genetics, Evolution and Environment, University College London, London, UK.
  • Balding DJ; 1] Department of Genetics, Evolution and Environment, University College London, London, UK. [2] University College London Genetics Institute, University College London, London, UK.
  • Balloux F; 1] Department of Genetics, Evolution and Environment, University College London, London, UK. [2] University College London Genetics Institute, University College London, London, UK.
  • Durbin R; Wellcome Trust Sanger Institute, Cambridge, UK.
  • Bähler J; 1] Department of Genetics, Evolution and Environment, University College London, London, UK. [2] University College London Genetics Institute, University College London, London, UK.
Nat Genet ; 47(3): 235-41, 2015 Mar.
Article in En | MEDLINE | ID: mdl-25665008
ABSTRACT
Natural variation within species reveals aspects of genome evolution and function. The fission yeast Schizosaccharomyces pombe is an important model for eukaryotic biology, but researchers typically use one standard laboratory strain. To extend the usefulness of this model, we surveyed the genomic and phenotypic variation in 161 natural isolates. We sequenced the genomes of all strains, finding moderate genetic diversity (π = 3 × 10(-3) substitutions/site) and weak global population structure. We estimate that dispersal of S. pombe began during human antiquity (∼340 BCE), and ancestors of these strains reached the Americas at ∼1623 CE. We quantified 74 traits, finding substantial heritable phenotypic diversity. We conducted 223 genome-wide association studies, with 89 traits showing at least one association. The most significant variant for each trait explained 22% of the phenotypic variance on average, with indels having larger effects than SNPs. This analysis represents a rich resource to examine genotype-phenotype relationships in a tractable model.
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Schizosaccharomyces / Genome, Fungal Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2015 Document type: Article Affiliation country: United kingdom
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Schizosaccharomyces / Genome, Fungal Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2015 Document type: Article Affiliation country: United kingdom