Predictive role of HER2/neu, topoisomerase-II-alpha, and tissue inhibitor of metalloproteinases (TIMP-1) for response to adjuvant taxane-based chemotherapy in patients with intermediate-risk breast cancer: results from the WSG-AGO EC-Doc trial.

Erber, Ramona; Gluz, Oleg; Brünner, Nils; Kreipe, Hans Heinrich; Pelz, Enrico; Kates, Ronald; Bartels, Annette; Huober, Jens; Mohrmann, Svjetlana; Moustafa, Zehra; Liedtke, Cornelia; Möbus, Volker; Augustin, Doris; Thomssen, Christoph; Jänicke, Fritz; Kiechle, Marion; Kuhn, Walther; Nitz, Ulrike; Harbeck, Nadia; Hartmann, Arndt

Erber, Ramona; Gluz, Oleg; Brünner, Nils; Kreipe, Hans Heinrich; Pelz, Enrico; Kates, Ronald; Bartels, Annette; Huober, Jens; Mohrmann, Svjetlana; Moustafa, Zehra; Liedtke, Cornelia; Möbus, Volker; Augustin, Doris; Thomssen, Christoph; Jänicke, Fritz; Kiechle, Marion; Kuhn, Walther; Nitz, Ulrike; Harbeck, Nadia; Hartmann, Arndt.

Affiliation

Erber R; Institute of Pathology, University Erlangen-Nürnberg, Krankenhausstraße 8-10, 91054, Erlangen, Germany, Ramona.erber@uk-erlangen.de.

Breast Cancer Res Treat ; 150(2): 279-88, 2015 Apr.

Article in En | MEDLINE | ID: mdl-25721604

Subject(s)

Antigens, Neoplasm/metabolism; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Biomarkers, Tumor/metabolism; Breast Neoplasms/drug therapy; DNA Topoisomerases, Type II/metabolism; DNA-Binding Proteins/metabolism; Receptor, ErbB-2/metabolism; Tissue Inhibitor of Metalloproteinase-1/metabolism; Antigens, Neoplasm/genetics; Breast Neoplasms/metabolism; Breast Neoplasms/mortality; Chemotherapy, Adjuvant; DNA Topoisomerases, Type II/genetics; DNA-Binding Proteins/genetics; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Middle Aged; Multivariate Analysis; Prognosis; Proportional Hazards Models; Receptor, ErbB-2/genetics; Risk; Taxoids/administration & dosage; Treatment Outcome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Biomarkers, Tumor / DNA Topoisomerases, Type II / Receptor, ErbB-2 / Tissue Inhibitor of Metalloproteinase-1 / DNA-Binding Proteins / Antigens, Neoplasm Type of study: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Middle aged Language: En Journal: Breast Cancer Res Treat Year: 2015 Document type: Article Country of publication: Netherlands

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