Silencing the alarms: Innate immune antagonism by rotavirus NSP1 and VP3.
Virology
; 479-480: 75-84, 2015 May.
Article
in En
| MEDLINE
| ID: mdl-25724417
ABSTRACT
The innate immune response involves a broad array of pathogen sensors that stimulate the production of interferons (IFNs) to induce an antiviral state. Rotavirus, a significant cause of childhood gastroenteritis and a member of the Reoviridae family of segmented, double-stranded RNA viruses, encodes at least two direct antagonists of host innate immunity NSP1 and VP3. NSP1, a putative E3 ubiquitin ligase, mediates the degradation of cellular factors involved in both IFN induction and downstream signaling. VP3, the viral capping enzyme, utilizes a 2H-phosphodiesterase domain to prevent activation of the cellular oligoadenylate synthase (OAS)/RNase L pathway. Computational, molecular, and biochemical studies have provided key insights into the structural and mechanistic basis of innate immune antagonism by NSP1 and VP3 of group A rotaviruses (RVA). Future studies with non-RVA isolates will be essential to understand how other rotavirus species evade host innate immune responses.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Viral Nonstructural Proteins
/
Rotavirus
/
Capsid Proteins
/
Host-Pathogen Interactions
/
Immune Evasion
/
Immunity, Innate
Language:
En
Journal:
Virology
Year:
2015
Document type:
Article
Affiliation country:
United States