Compared to sucrose, previous consumption of fructose and glucose monosaccharides reduces survival and fitness of female mice.
J Nutr
; 145(3): 434-41, 2015 Mar.
Article
in En
| MEDLINE
| ID: mdl-25733457
ABSTRACT
BACKGROUND:
Intake of added sugar has been shown to correlate with many human metabolic diseases, and rodent models have characterized numerous aspects of the resulting disease phenotypes. However, there is a controversy about whether differential health effects occur because of the consumption of either of the two common types of added sugar-high-fructose corn syrup (fructose and glucose monosaccharides; F/G) or table sugar (sucrose, a fructose and glucose disaccharide).OBJECTIVES:
We tested the equivalence of sucrose- vs. F/G-containing diets on mouse (Mus musculus) longevity, reproductive success, and social dominance.METHODS:
We fed wild-derived mice, outbred mice descended from wild-caught ancestors, a diet in which 25% of the calories came from either an equal ratio of F/G or an isocaloric amount of sucrose (both diets had 63% of total calories as carbohydrates). Exposure lasted 40 wk, starting at weaning (21 d of age), and then mice (104 females and 56 males) were released into organismal performances assays-seminatural enclosures where mice competed for territories, resources, and mates for 32 wk. Within enclosures all mice consumed the F/G diet.RESULTS:
Females initially fed the F/G diet experienced a mortality rate 1.9 times the rate (P = 0.012) and produced 26.4% fewer offspring than females initially fed sucrose (P = 0.001). This reproductive deficiency was present before mortality differences, suggesting the F/G diet was causing physiologic performance deficits prior to mortality. No differential patterns in survival, reproduction, or social dominance were observed in males, indicating a sex-specific outcome of exposure.CONCLUSION:
This study provides experimental evidence that the consumption of human-relevant levels of F/G is more deleterious than an isocaloric amount of sucrose for key organism-level health measures in female mice.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dietary Sucrose
/
Fructose
/
Glucose
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
J Nutr
Year:
2015
Document type:
Article