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The therapeutic effects of bone marrow mesenchymal stem cells after optic nerve damage in the adult rat.
Tan, HaiBo; Kang, Xin; Lu, ShiHeng; Liu, Lin.
Affiliation
  • Tan H; Department of Ophthalmology, RenJi Hospital, The School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China.
  • Kang X; Department of Clinical Pharmacology, Changhai Hospital Affiliated Second Military Medical University, Shanghai, People's Republic of China.
  • Lu S; Department of Ophthalmology, RenJi Hospital, The School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China.
  • Liu L; Department of Ophthalmology, RenJi Hospital, The School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China.
Clin Interv Aging ; 10: 487-90, 2015.
Article in En | MEDLINE | ID: mdl-25733825
ABSTRACT
Optic nerve trauma is a common occurrence that results in irreversible blindness. Currently, no effective strategies are known to prevent optic nerve degeneration. We assessed the therapeutic effects of bone marrow mesenchymal stem cells (BMSCs) after optic nerve crush in the adult rat. Our results showed that BMSCs significantly promoted the regeneration of injured axons compared with phosphate buffered saline alone. Therefore, BMSC transplantation may be effective for the treatment of central nervous system disorders.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Optic Nerve Injuries / Mesenchymal Stem Cell Transplantation Limits: Animals Language: En Journal: Clin Interv Aging Journal subject: GERIATRIA Year: 2015 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Optic Nerve Injuries / Mesenchymal Stem Cell Transplantation Limits: Animals Language: En Journal: Clin Interv Aging Journal subject: GERIATRIA Year: 2015 Document type: Article