In vitro activities of hexaazatrinaphthylenes against Leishmania spp.
Antimicrob Agents Chemother
; 59(5): 2867-74, 2015 May.
Article
in En
| MEDLINE
| ID: mdl-25753635
ABSTRACT
The in vitro activity of a novel group of compounds, hexaazatrinaphthylene derivatives, against two species of Leishmania is described in this study. These compounds showed a significant dose-dependent inhibition effect on the proliferation of the parasites, with 50% inhibitory concentrations (IC(50)s) ranging from 1.23 to 25.05 µM against the promastigote stage and 0.5 to 0.7 µM against intracellular amastigotes. Also, a cytotoxicity assay was carried out to in order to evaluate the possible toxic effects of these compounds. Moreover, different assays were performed to determine the type of cell death induced after incubation with these compounds. The obtained results highlight the potential use of hexaazatrinaphthylene derivatives against Leishmania species, and further studies should be undertaken to establish them as novel leishmanicidal therapeutic agents.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Leishmania
/
Naphthalenes
/
Antiprotozoal Agents
Language:
En
Journal:
Antimicrob Agents Chemother
Year:
2015
Document type:
Article
Affiliation country:
Spain