Light-controlled endosomal escape of the novel CD133-targeting immunotoxin AC133-saporin by photochemical internalization - A minimally invasive cancer stem cell-targeting strategy.

Bostad, Monica; Olsen, Cathrine Elisabeth; Peng, Qian; Berg, Kristian; Høgset, Anders; Selbo, Pål Kristian

Bostad, Monica; Olsen, Cathrine Elisabeth; Peng, Qian; Berg, Kristian; Høgset, Anders; Selbo, Pål Kristian.

Affiliation

Bostad M; Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway; Cancer Stem Cell Innovation Center (SFI-CAST), Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Olsen CE; Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway; Cancer Stem Cell Innovation Center (SFI-CAST), Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Peng Q; Department of Pathology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Berg K; Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Høgset A; Cancer Stem Cell Innovation Center (SFI-CAST), Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway; PCI Biotech AS, Lysaker, Norway.
Selbo PK; Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway; Cancer Stem Cell Innovation Center (SFI-CAST), Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway. Electronic address: selb

J Control Release ; 206: 37-48, 2015 May 28.

Article in En | MEDLINE | ID: mdl-25758331

Subject(s)

Adenocarcinoma/drug therapy; Colorectal Neoplasms/drug therapy; Immunotoxins/administration & dosage; Photosensitizing Agents/administration & dosage; Ribosome Inactivating Proteins, Type 1/administration & dosage; Adenocarcinoma/metabolism; Adenocarcinoma/pathology; Cell Line, Tumor; Colon/drug effects; Colon/metabolism; Colon/pathology; Colorectal Neoplasms/metabolism; Colorectal Neoplasms/pathology; Drug Delivery Systems; Endosomes/drug effects; Endosomes/metabolism; Humans; Immunotoxins/metabolism; Immunotoxins/pharmacology; Light; Neoplastic Stem Cells/drug effects; Neoplastic Stem Cells/metabolism; Photochemotherapy; Photosensitizing Agents/metabolism; Photosensitizing Agents/pharmacology; Rectum/drug effects; Rectum/metabolism; Rectum/pathology; Ribosome Inactivating Proteins, Type 1/metabolism; Ribosome Inactivating Proteins, Type 1/pharmacology; Saporins

Key words

Autophagy; CD133; Cancer stem cells; Cancer therapy; Controlled drug delivery; Endosomal escape; Immunotoxin; Photochemical internalization; Photodynamic therapy; Targeting

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Adenocarcinoma / Immunotoxins / Photosensitizing Agents / Ribosome Inactivating Proteins, Type 1 Limits: Humans Language: En Journal: J Control Release Journal subject: FARMACOLOGIA Year: 2015 Document type: Article Affiliation country: Norway Country of publication: Netherlands

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