A photoinduced cyclization cascade-total synthesis of (-)-leuconoxine.
Chemistry
; 21(17): 6355-7, 2015 Apr 20.
Article
in En
| MEDLINE
| ID: mdl-25761272
ABSTRACT
A protecting-group-free and enantioselective total synthesis of the monoterpenoid indole alkaloid (-)-leuconoxine was accomplished. The key step comprises a novel photoinduced domino macrocyclization/transannular cyclization involving the Witkop cyclization, for which additional mechanistic evidence is provided. This process furnishes a diaza[5.5.6.6]fenestrane skeleton, which is a hitherto unprecedented structure element.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Indole Alkaloids
/
Secologanin Tryptamine Alkaloids
Language:
En
Journal:
Chemistry
Journal subject:
QUIMICA
Year:
2015
Document type:
Article