Latent herpes simplex virus 1 infection does not induce apoptosis in human trigeminal Ganglia.
J Virol
; 89(10): 5747-50, 2015 May.
Article
in En
| MEDLINE
| ID: mdl-25762734
ABSTRACT
Herpes simplex virus 1 (HSV-1) can establish lifelong latency in human trigeminal ganglia. Latently infected ganglia contain CD8(+) T cells, which secrete granzyme B and are thus capable of inducing neuronal apoptosis. Using immunohistochemistry and single-cell reverse transcription-quantitative PCR (RT-qPCR), higher frequency and transcript levels of caspase-3 were found in HSV-1-negative compared to HSV-1-positive ganglia and neurons, respectively. No terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling (TUNEL) assay-positive neurons were detected. The infiltrating T cells do not induce apoptosis in latently infected neurons.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Trigeminal Ganglion
/
Herpesvirus 1, Human
/
Herpes Simplex
Limits:
Humans
Language:
En
Journal:
J Virol
Year:
2015
Document type:
Article
Affiliation country:
Germany