MutY-glycosylase: an overview on mutagenesis and activities beyond the GO system.
Mutat Res
; 769: 119-31, 2014 Nov.
Article
in En
| MEDLINE
| ID: mdl-25771731
ABSTRACT
MutY is a glycosylase known for its role in DNA base excision repair (BER). It is critically important in the prevention of DNA mutations derived from 7,8-dihydro-8-oxoguanine (8-oxoG), which are the major lesions resulting from guanine oxidation. MutY has been described as a DNA repair enzyme in the GO system responsible for removing adenine residues misincorporated in 8-oxoGA mispairs, avoiding GC to TA mutations. Further studies have shown that this enzyme binds to other mispairs, interacts with several enzymes, avoids different transversions/transitions in DNA, and is involved in different repair pathways. Additional activities have been reported for MutY, such as the repair of replication errors in newly synthesized DNA strands through its glycosylase activity. Moreover, MutY is a highly conserved enzyme present in several prokaryotic and eukaryotic organisms. MutY defects are associated with a hereditary colorectal cancer syndrome termed MUTYH-associated polyposis (MAP). Here, we have reviewed the roles of MutY in the repair of mispaired bases in DNA as well as its activities beyond the GO system.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mutagenesis
/
DNA Glycosylases
/
Guanosine
Limits:
Animals
/
Humans
Language:
En
Journal:
Mutat Res
Year:
2014
Document type:
Article
Affiliation country:
Brazil