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GSK256073 acutely regulates NEFA levels via HCA2 agonism but does not achieve durable glycaemic control in type 2 diabetes. A randomised trial.
Dobbins, Robert; Byerly, Robert; Gaddy, Riley; Gao, Feng; Mahar, Kelly; Napolitano, Antonella; Ambery, Philip; Le Monnier de Gouville, Anne-Charlotte.
Affiliation
  • Dobbins R; GlaxoSmithKline, Drug Discovery, Research Triangle Park, NC, USA.
  • Byerly R; GlaxoSmithKline, Drug Discovery, Research Triangle Park, NC, USA.
  • Gaddy R; GlaxoSmithKline, Drug Discovery, Research Triangle Park, NC, USA.
  • Gao F; GlaxoSmithKline, Quantitative Sciences, Upper Merion, PA, USA.
  • Mahar K; GlaxoSmithKline, Quantitative Sciences, Upper Merion, PA, USA.
  • Napolitano A; GlaxoSmithKline, Immuno-Inflammation Therapeutic Area, Stevenage, UK.
  • Ambery P; Department of Endocrinology and Diabetes, Addenbrooke's Hospital, Cambridge, UK.
  • Le Monnier de Gouville AC; GlaxoSmithKline, Drug Discovery, Laboratoire GSK, 27av du Quebec, 91951 les Ulis Cedex, France. Electronic address: anne-charlotte.m.degouville@gsk.com.
Eur J Pharmacol ; 755: 95-101, 2015 May 15.
Article in En | MEDLINE | ID: mdl-25773496
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Xanthines / Receptors, G-Protein-Coupled / Diabetes Mellitus, Type 2 Type of study: Clinical_trials Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Eur J Pharmacol Year: 2015 Document type: Article Affiliation country: United States Country of publication: Netherlands
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Xanthines / Receptors, G-Protein-Coupled / Diabetes Mellitus, Type 2 Type of study: Clinical_trials Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Eur J Pharmacol Year: 2015 Document type: Article Affiliation country: United States Country of publication: Netherlands