Relationship of pathologic factors to efficacy of sorafenib treatment in patients with metastatic clear cell renal cell carcinoma.
Am J Clin Pathol
; 143(4): 492-9, 2015 Apr.
Article
in En
| MEDLINE
| ID: mdl-25780000
ABSTRACT
OBJECTIVES:
To evaluate the predictive value of growth patterns in patients undergoing sorafenib treatment for metastatic clear cell renal cell carcinomas (CCRCCs).METHODS:
Forty-eight patients were analyzed, each of whom underwent nephrectomy and received sorafenib treatment for metastatic CCRCC. Progression-free survival (PFS) was predicted using pathologic parameters, including pathologic stage, Fuhrman nuclear grade (FNG), the presence of a sarcomatoid component, lymphovascular invasion, tumor necrosis, and growth pattern.RESULTS:
Three (6%) patients showed partial response, 20 (42%) patients showed stable disease, and 25 (52%) patients showed progressive disease. Univariate analyses demonstrated that FNG, the presence of a sarcomatoid component, tumor necrosis, and growth pattern were significantly associated with PFS. In the multivariate analysis, growth pattern was the only parameter that was significantly and independently predictive of PFS.CONCLUSIONS:
As a novel histologic prognostic parameter, growth pattern may be useful for predicting response to sorafenib treatment.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenylurea Compounds
/
Carcinoma, Renal Cell
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Niacinamide
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Kidney Neoplasms
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Antineoplastic Agents
Type of study:
Prognostic_studies
Limits:
Adult
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Aged
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Aged80
/
Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Am J Clin Pathol
Year:
2015
Document type:
Article