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Functional elucidation of miR-494 in the tumorigenesis of nasopharyngeal carcinoma.
Duan, Hong-Fang; Li, Xiao-Qing; Hu, Hong-Yi; Li, Yu-Chi; Cai, Zhi; Mei, Xue-Shuang; Yu, Peng; Nie, Li-Ping; Zhang, Wei; Yu, Zhen-Dong; Nie, Guo-Hui.
Affiliation
  • Duan HF; Department of Otolaryngological, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China.
  • Li XQ; Guangzhou Medical University, 510000, Guangzhou, Guangdong Province, China.
  • Hu HY; Department of Clinical Laboratory, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China.
  • Li YC; Shantou University Medical College, 515041, Shantou, Guangdong Province, China.
  • Cai Z; Department of Otolaryngological, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China.
  • Mei XS; Shantou University Medical College, 515041, Shantou, Guangdong Province, China.
  • Yu P; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Shenzhen PKU-HKUST Medical Center, Institute of Urology, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China.
  • Nie LP; Department of Otolaryngological, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China.
  • Zhang W; Department of Otolaryngological, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China.
  • Yu ZD; Department of Otolaryngological, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China.
  • Nie GH; Department of Clinical Laboratory, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China.
Tumour Biol ; 36(9): 6679-89, 2015 Sep.
Article in En | MEDLINE | ID: mdl-25809707
ABSTRACT
Nasopharyngeal carcinoma has very high incidence and high mortality worldwide. MiRNA is related to the tumorigenesis and metastasis of a variety of tumors. In the present study, we verify that the expression of miR-494 in NPC tissues and NPC-derived cells was down-regulated, respectively. The proliferation, colony formation, migration, and invasion of NPC-derived cells were suppressed, while the cell apoptosis was promoted, when miR-494 was over-expressed in these cells. GALNT7 and CDK16 were confirmed to be the direct targets of miR-494. These results suggested that miR-494 play an inhibitory role in the tumorigenesis of NPC.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nasopharyngeal Neoplasms / N-Acetylgalactosaminyltransferases / Cyclin-Dependent Kinases / MicroRNAs Limits: Humans Language: En Journal: Tumour Biol Journal subject: NEOPLASIAS Year: 2015 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nasopharyngeal Neoplasms / N-Acetylgalactosaminyltransferases / Cyclin-Dependent Kinases / MicroRNAs Limits: Humans Language: En Journal: Tumour Biol Journal subject: NEOPLASIAS Year: 2015 Document type: Article Affiliation country: China