Functional elucidation of miR-494 in the tumorigenesis of nasopharyngeal carcinoma.
Tumour Biol
; 36(9): 6679-89, 2015 Sep.
Article
in En
| MEDLINE
| ID: mdl-25809707
ABSTRACT
Nasopharyngeal carcinoma has very high incidence and high mortality worldwide. MiRNA is related to the tumorigenesis and metastasis of a variety of tumors. In the present study, we verify that the expression of miR-494 in NPC tissues and NPC-derived cells was down-regulated, respectively. The proliferation, colony formation, migration, and invasion of NPC-derived cells were suppressed, while the cell apoptosis was promoted, when miR-494 was over-expressed in these cells. GALNT7 and CDK16 were confirmed to be the direct targets of miR-494. These results suggested that miR-494 play an inhibitory role in the tumorigenesis of NPC.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Nasopharyngeal Neoplasms
/
N-Acetylgalactosaminyltransferases
/
Cyclin-Dependent Kinases
/
MicroRNAs
Limits:
Humans
Language:
En
Journal:
Tumour Biol
Journal subject:
NEOPLASIAS
Year:
2015
Document type:
Article
Affiliation country:
China