MicroRNA-124 inhibits cancer cell growth through PTB1/PKM1/PKM2 feedback cascade in colorectal cancer.

Taniguchi, Kohei; Sugito, Nobuhiko; Kumazaki, Minami; Shinohara, Haruka; Yamada, Nami; Nakagawa, Yoshihito; Ito, Yuko; Otsuki, Yoshinori; Uno, Bunji; Uchiyama, Kazuhisa; Akao, Yukihiro

Taniguchi, Kohei; Sugito, Nobuhiko; Kumazaki, Minami; Shinohara, Haruka; Yamada, Nami; Nakagawa, Yoshihito; Ito, Yuko; Otsuki, Yoshinori; Uno, Bunji; Uchiyama, Kazuhisa; Akao, Yukihiro.

Affiliation

Taniguchi K; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan; Department of General and Gastroenterological Surgery, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan.
Sugito N; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Kumazaki M; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Shinohara H; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Yamada N; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Nakagawa Y; Department of Gastroenterology, Fujita Health University, School of Medicine, 1-98 Dengakugakubo Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.
Ito Y; Department of Anatomy and Cell Biology, Division of Life Sciences, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan.
Otsuki Y; Department of Anatomy and Cell Biology, Division of Life Sciences, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan.
Uno B; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Uchiyama K; Department of General and Gastroenterological Surgery, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan.
Akao Y; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan. Electronic address: yakao@gifu-u.ac.jp.

Cancer Lett ; 363(1): 17-27, 2015 Jul 10.

Article in En | MEDLINE | ID: mdl-25818238

Subject(s)

Carrier Proteins/metabolism; Colorectal Neoplasms/enzymology; Heterogeneous-Nuclear Ribonucleoproteins/metabolism; Membrane Proteins/metabolism; MicroRNAs/metabolism; Polypyrimidine Tract-Binding Protein/metabolism; Thyroid Hormones/metabolism; 3' Untranslated Regions; Animals; Apoptosis; Autophagy; Carrier Proteins/genetics; Case-Control Studies; Cell Line, Tumor; Colorectal Neoplasms/genetics; Colorectal Neoplasms/pathology; Colorectal Neoplasms/therapy; Energy Metabolism; Feedback, Physiological; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genetic Therapy/methods; Heterogeneous-Nuclear Ribonucleoproteins/genetics; Humans; Male; Membrane Proteins/genetics; Mice, Inbred BALB C; Mice, Nude; MicroRNAs/administration & dosage; MicroRNAs/genetics; Oxidative Stress; Polypyrimidine Tract-Binding Protein/genetics; RNA Interference; Thyroid Hormones/genetics; Time Factors; Transfection; Tumor Burden; Xenograft Model Antitumor Assays; Thyroid Hormone-Binding Proteins

Key words

Colorectal cancer; PKM; PTB1; Warburg effect; miR-124

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thyroid Hormones / Colorectal Neoplasms / Carrier Proteins / Polypyrimidine Tract-Binding Protein / Heterogeneous-Nuclear Ribonucleoproteins / MicroRNAs / Membrane Proteins Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: Cancer Lett Year: 2015 Document type: Article Affiliation country: Japan Country of publication: Ireland

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