DNAM-1 expression marks an alternative program of NK cell maturation.
Cell Rep
; 11(1): 85-97, 2015 Apr 07.
Article
in En
| MEDLINE
| ID: mdl-25818301
ABSTRACT
Natural killer (NK) cells comprise a heterogeneous population of cells important for pathogen defense and cancer surveillance. However, the functional significance of this diversity is not fully understood. Here, we demonstrate through transcriptional profiling and functional studies that the activating receptor DNAM-1 (CD226) identifies two distinct NK cell functional subsets DNAM-1(+) and DNAM-1(-) NK cells. DNAM-1(+) NK cells produce high levels of inflammatory cytokines, have enhanced interleukin 15 signaling, and proliferate vigorously. By contrast, DNAM-1(-) NK cells that differentiate from DNAM-1(+) NK cells have greater expression of NK-cell-receptor-related genes and are higher producers of MIP1 chemokines. Collectively, our data reveal the existence of a functional program of NK cell maturation marked by DNAM-1 expression.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Killer Cells, Natural
/
Antigens, Differentiation, T-Lymphocyte
/
Cell Lineage
Limits:
Humans
Language:
En
Journal:
Cell Rep
Year:
2015
Document type:
Article
Affiliation country:
France