Population pharmacokinetics of dolutegravir in HIV-infected treatment-naive patients.

Zhang, Jianping; Hayes, Siobhán; Sadler, Brian M; Minto, Ilisse; Brandt, Julie; Piscitelli, Steve; Min, Sherene; Song, Ivy H

Zhang, Jianping; Hayes, Siobhán; Sadler, Brian M; Minto, Ilisse; Brandt, Julie; Piscitelli, Steve; Min, Sherene; Song, Ivy H.

Affiliation

Zhang J; Clinical Pharmacology, GlaxoSmithKline, Research Triangle Park, NC, USA.
Hayes S; ICON, Marlow, UK.
Sadler BM; ICON, Marlow, UK.
Minto I; GlaxoSmithKline, Research Triangle Park, NC, USA.
Brandt J; GlaxoSmithKline, Research Triangle Park, NC, USA.
Piscitelli S; Clinical Pharmacology, GlaxoSmithKline, Research Triangle Park, NC, USA.
Min S; GlaxoSmithKline, Research Triangle Park, NC, USA.
Song IH; Clinical Pharmacology, GlaxoSmithKline, Research Triangle Park, NC, USA.

Br J Clin Pharmacol ; 80(3): 502-14, 2015 Sep.

Article in En | MEDLINE | ID: mdl-25819132

Subject(s)

HIV Infections/drug therapy; HIV Integrase Inhibitors/pharmacokinetics; Heterocyclic Compounds, 3-Ring/pharmacokinetics; Models, Biological; Adult; Area Under Curve; Computer Simulation; HIV Infections/blood; HIV Integrase Inhibitors/blood; HIV Integrase Inhibitors/therapeutic use; Healthy Volunteers; Heterocyclic Compounds, 3-Ring/blood; Heterocyclic Compounds, 3-Ring/therapeutic use; Humans; Oxazines; Piperazines; Pyridones; Randomized Controlled Trials as Topic

Key words

dolutegravir; integrase inhibitor; population pharmacokinetics; treatment-naive

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / HIV Integrase Inhibitors / Heterocyclic Compounds, 3-Ring / Models, Biological Type of study: Clinical_trials / Prognostic_studies Limits: Adult / Humans Language: En Journal: Br J Clin Pharmacol Year: 2015 Document type: Article Affiliation country: United States Country of publication: United kingdom

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