Brain/metabolism; Multiple Sclerosis/metabolism; Nerve Tissue Proteins/physiology; Amyloid/metabolism; Anti-Inflammatory Agents/therapeutic use; Antioxidants/physiology; Brain/immunology; Brain/pathology; Cytokines/physiology; Female; Gasotransmitters/physiology; Gasotransmitters/therapeutic use; Humans; Inflammation; Lipids/immunology; Lipids/physiology; Lymphocyte Subsets/drug effects; Lymphocyte Subsets/immunology; Male; Multiple Sclerosis/drug therapy; Multiple Sclerosis/immunology; Multiple Sclerosis/pathology; Myelin Sheath/chemistry; Nerve Growth Factors/physiology; Neuroprotective Agents/therapeutic use; Oxidative Stress; Receptors, Cytoplasmic and Nuclear/physiology; Serpins/physiology; alpha-Crystallin B Chain/physiology; gamma-Aminobutyric Acid/physiology