Profiling cancer gene mutations in longitudinal epithelial ovarian cancer biopsies by targeted next-generation sequencing: a retrospective study.

Beltrame, L; Di Marino, M; Fruscio, R; Calura, E; Chapman, B; Clivio, L; Sina, F; Mele, C; Iatropoulos, P; Grassi, T; Fotia, V; Romualdi, C; Martini, P; Noris, M; Paracchini, L; Craparotta, I; Petrillo, M; Milani, R; Perego, P; Ravaggi, A; Zambelli, A; Ronchetti, E; D'Incalci, M; Marchini, S

Beltrame, L; Di Marino, M; Fruscio, R; Calura, E; Chapman, B; Clivio, L; Sina, F; Mele, C; Iatropoulos, P; Grassi, T; Fotia, V; Romualdi, C; Martini, P; Noris, M; Paracchini, L; Craparotta, I; Petrillo, M; Milani, R; Perego, P; Ravaggi, A; Zambelli, A; Ronchetti, E; D'Incalci, M; Marchini, S.

Affiliation

Beltrame L; Department of Oncology, Centro di Ricerche Cliniche per le Malattie Rare 'ALDO e CELE DACCO'', IRCCS 'Mario Negri' Institute for Pharmacological Research, Milano.
Di Marino M; Department of Oncology, Centro di Ricerche Cliniche per le Malattie Rare 'ALDO e CELE DACCO'', IRCCS 'Mario Negri' Institute for Pharmacological Research, Milano.
Fruscio R; Clinic of Obstetrics and Gynecology, University of Milano-Bicocca, San Gerardo Hospital, Monza.
Calura E; Department of Biology, University of Padova, Padova, Italy.
Chapman B; Bioinformatics Core, Harvard School of Public Health, Boston, USA.
Clivio L; Department of Oncology, Centro di Ricerche Cliniche per le Malattie Rare 'ALDO e CELE DACCO'', IRCCS 'Mario Negri' Institute for Pharmacological Research, Milano.
Sina F; Clinic of Obstetrics and Gynecology, University of Milano-Bicocca, San Gerardo Hospital, Monza.
Mele C; Department of Molecular Medicine Laboratory, Immunology and Genetic of Rare Diseases and Organ Transplantation, Centro di Ricerche Cliniche per le Malattie Rare 'ALDO e CELE DACCO'', IRCCS 'Mario Negri' Institute for Pharmacological Research, Milano.
Iatropoulos P; Department of Molecular Medicine Laboratory, Immunology and Genetic of Rare Diseases and Organ Transplantation, Centro di Ricerche Cliniche per le Malattie Rare 'ALDO e CELE DACCO'', IRCCS 'Mario Negri' Institute for Pharmacological Research, Milano.
Grassi T; Clinic of Obstetrics and Gynecology, University of Milano-Bicocca, San Gerardo Hospital, Monza.
Fotia V; PhD Program in Experimental Medicine, University of Pavia, Pavia.
Romualdi C; Department of Biology, University of Padova, Padova, Italy.
Martini P; Department of Biology, University of Padova, Padova, Italy.
Noris M; Department of Molecular Medicine Laboratory, Immunology and Genetic of Rare Diseases and Organ Transplantation, Centro di Ricerche Cliniche per le Malattie Rare 'ALDO e CELE DACCO'', IRCCS 'Mario Negri' Institute for Pharmacological Research, Milano.
Paracchini L; Department of Oncology, Centro di Ricerche Cliniche per le Malattie Rare 'ALDO e CELE DACCO'', IRCCS 'Mario Negri' Institute for Pharmacological Research, Milano.
Craparotta I; Department of Oncology, Centro di Ricerche Cliniche per le Malattie Rare 'ALDO e CELE DACCO'', IRCCS 'Mario Negri' Institute for Pharmacological Research, Milano.
Petrillo M; Gynecologic Oncology Unit, Catholic University of the Sacred Heart, Rome.
Milani R; Clinic of Obstetrics and Gynecology, University of Milano-Bicocca, San Gerardo Hospital, Monza.
Perego P; Department of Pathology, University of Milano-Bicocca, San Gerardo Hospital, Monza.
Ravaggi A; Division of Gynecologic Oncology, 'Angelo Nocivelli' Institute of Molecular Medicine, University of Brescia, Brescia.
Zambelli A; Unit of Medical Oncology, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo.
Ronchetti E; Laboratory of Experimental Oncology and Pharmacogenomics, IRCCS Salvatore Maugeri Foundation, Pavia, Italy.
D'Incalci M; Department of Oncology, Centro di Ricerche Cliniche per le Malattie Rare 'ALDO e CELE DACCO'', IRCCS 'Mario Negri' Institute for Pharmacological Research, Milano maurizio.dincalci@marionegri.it.
Marchini S; Department of Oncology, Centro di Ricerche Cliniche per le Malattie Rare 'ALDO e CELE DACCO'', IRCCS 'Mario Negri' Institute for Pharmacological Research, Milano.

Ann Oncol ; 26(7): 1363-71, 2015 Jul.

Article in En | MEDLINE | ID: mdl-25846551

Subject(s)

Adenocarcinoma, Clear Cell/genetics; Adenocarcinoma, Mucinous/genetics; Cystadenocarcinoma, Serous/genetics; Endometrial Neoplasms/genetics; Genes, Neoplasm/genetics; High-Throughput Nucleotide Sequencing/methods; Mutation/genetics; Ovarian Neoplasms/genetics; Adenocarcinoma, Clear Cell/mortality; Adenocarcinoma, Clear Cell/secondary; Adenocarcinoma, Clear Cell/therapy; Adenocarcinoma, Mucinous/mortality; Adenocarcinoma, Mucinous/secondary; Adenocarcinoma, Mucinous/therapy; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Biopsy; Combined Modality Therapy; Cystadenocarcinoma, Serous/mortality; Cystadenocarcinoma, Serous/secondary; Cystadenocarcinoma, Serous/therapy; Drug Resistance, Neoplasm/genetics; Endometrial Neoplasms/mortality; Endometrial Neoplasms/secondary; Endometrial Neoplasms/therapy; Female; Follow-Up Studies; Homologous Recombination; Humans; Longitudinal Studies; Lymphatic Metastasis; Middle Aged; Neoplasm Grading; Neoplasm Recurrence, Local/genetics; Neoplasm Recurrence, Local/mortality; Neoplasm Recurrence, Local/pathology; Neoplasm Recurrence, Local/therapy; Neoplasm Staging; Ovarian Neoplasms/mortality; Ovarian Neoplasms/pathology; Ovarian Neoplasms/therapy; Prognosis; Retrospective Studies; Survival Rate

Key words

NGS; epithelial ovarian cancer; matched tumor biopsies

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Endometrial Neoplasms / Cystadenocarcinoma, Serous / Adenocarcinoma, Clear Cell / Adenocarcinoma, Mucinous / Genes, Neoplasm / High-Throughput Nucleotide Sequencing / Mutation Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: Ann Oncol Journal subject: NEOPLASIAS Year: 2015 Document type: Article Country of publication: United kingdom

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