Association of decreased mRNA expression of multidrug and toxin extrusion protein 1 in peripheral blood cells with the development of flutamide-induced liver injury.

Nakano, Kazuhiko; Ando, Hitoshi; Kurokawa, Shinsuke; Hosohata, Keiko; Ushijima, Kentarou; Takada, Makoto; Tateishi, Masato; Yonezawa, Atsushi; Masuda, Satohiro; Matsubara, Kazuo; Inui, Ken-Ichi; Morita, Tatsuo; Fujimura, Akio

Nakano, Kazuhiko; Ando, Hitoshi; Kurokawa, Shinsuke; Hosohata, Keiko; Ushijima, Kentarou; Takada, Makoto; Tateishi, Masato; Yonezawa, Atsushi; Masuda, Satohiro; Matsubara, Kazuo; Inui, Ken-Ichi; Morita, Tatsuo; Fujimura, Akio.

Affiliation

Nakano K; Department of Urology, Jichi Medical University, Shimotsuke, Japan.

Cancer Chemother Pharmacol ; 75(6): 1191-7, 2015 Jun.

Article in En | MEDLINE | ID: mdl-25862351

Subject(s)

Antineoplastic Agents/adverse effects; Chemical and Drug Induced Liver Injury/genetics; Flutamide/adverse effects; Organic Cation Transport Proteins/genetics; RNA, Messenger/genetics; Aged; Alanine Transaminase/metabolism; Androgen Antagonists/adverse effects; Androgen Antagonists/therapeutic use; Animals; Antineoplastic Agents/therapeutic use; Flutamide/therapeutic use; Humans; Male; Mice; Mice, Knockout; Prospective Studies; Prostatic Neoplasms/drug therapy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Messenger / Organic Cation Transport Proteins / Chemical and Drug Induced Liver Injury / Flutamide / Antineoplastic Agents Type of study: Observational_studies / Risk_factors_studies Limits: Aged / Animals / Humans / Male Language: En Journal: Cancer Chemother Pharmacol Year: 2015 Document type: Article Affiliation country: Japan Country of publication: Germany

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