Saturation of the biological response to orthodontic forces and its effect on the rate of tooth movement.
Orthod Craniofac Res
; 18 Suppl 1: 8-17, 2015 Apr.
Article
in En
| MEDLINE
| ID: mdl-25865529
ABSTRACT
OBJECTIVES:
Investigate the expression and activity of inflammatory markers in response to different magnitudes of orthodontic forces and correlate this response with other molecular and cellular events during orthodontic tooth movement. SETTING AND SAMPLE POPULATION CTOR Laboratory; 245 Sprague Dawley male rats. METHODS AND MATERIALS Control, sham, and 5 different experimental groups received different magnitudes of force on the right maxillary first molar using a coil spring. In the sham group, the spring was not activated. Control group did not receive any appliance. At days 1, 3, 7, 14, and 28, the maxillae were collected for RNA and protein analysis, immunohistochemistry, and micro-CT.RESULTS:
There was a linear relation between the force and the level of cytokine expression at lower magnitudes of force. Higher magnitudes of force did not increase the expression of cytokines. Activity of CCL2, CCL5, IL-1, TNF-α, RANKL, and number of osteoclasts reached a saturation point in response to higher magnitudes of force, with unchanged rate of tooth movement.CONCLUSION:
After a certain magnitude of force, there is a saturation in the biological response, and higher forces do not increase inflammatory markers, osteoclasts, nor the amount of tooth movement. Therefore, higher forces to accelerate the rate of tooth movement are not justified.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Orthodontic Wires
/
Tooth Movement Techniques
/
Cytokines
Limits:
Animals
Language:
En
Journal:
Orthod Craniofac Res
Journal subject:
ODONTOLOGIA
/
ORTODONTIA
Year:
2015
Document type:
Article
Affiliation country:
United States