[(18)F]6-fluoro-3,4-dihydroxy-L-phenylalanine--recent modern syntheses for an elusive radiotracer.
J Labelled Comp Radiopharm
; 58(5): 183-7, 2015 May 15.
Article
in En
| MEDLINE
| ID: mdl-25882075
ABSTRACT
[(18)F]6-fluoro-3,4-dihydroxy-L-phenylalanine ([(18)F]F-DOPA) has been known to be a useful radiotracer for over 30 years. Its widespread clinical use has been hampered by the lack of a robust, high yielding synthesis. This review summarises new developments in radiochemistry that are providing solutions to long standing problems involved in the synthesis of this important but elusive radiotracer. Considerable advances in nucleophilic synthesis have been achieved by optimising multistep strategies and using both hypervalent iodine chemistry and transition metal-mediated fluorinations allowing for the production of high specific activity [(18)F]F-DOPA.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dihydroxyphenylalanine
/
Radiopharmaceuticals
Language:
En
Journal:
J Labelled Comp Radiopharm
Year:
2015
Document type:
Article
Affiliation country:
United kingdom