Acute and chronic toxicity, cytochrome p450 enzyme inhibition, and HERG channel blockade studies with a polyherbal, ayurvedic formulation for inflammation.

Dey, Debendranath; Chaskar, Sunetra; Athavale, Nitin; Chitre, Deepa

Dey, Debendranath; Chaskar, Sunetra; Athavale, Nitin; Chitre, Deepa.

Affiliation

Dey D; Bioved Pharmaceuticals Pvt. Ltd., BAIF Bhawan, Z Wing, Warje Malwadi, Pune 411 052, India.
Chaskar S; Bioved Pharmaceuticals Pvt. Ltd., BAIF Bhawan, Z Wing, Warje Malwadi, Pune 411 052, India.
Athavale N; Bioved Pharmaceuticals Pvt. Ltd., BAIF Bhawan, Z Wing, Warje Malwadi, Pune 411 052, India.
Chitre D; Bioved Pharmaceuticals, Inc., 1929 O'Toole Way, San Jose, CA 95131, USA.

Biomed Res Int ; 2015: 971982, 2015.

Article in En | MEDLINE | ID: mdl-25893199

Subject(s)

Cytochrome P-450 Enzyme Inhibitors/pharmacology; Cytochrome P-450 Enzyme System/metabolism; Ether-A-Go-Go Potassium Channels/antagonists & inhibitors; Lipopolysaccharides/toxicity; Plant Preparations/pharmacology; Plants, Medicinal/chemistry; Animals; Cell Line; Cytochrome P-450 Enzyme Inhibitors/chemistry; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels/metabolism; Female; Humans; Inflammation/chemically induced; Inflammation/drug therapy; Inflammation/metabolism; Inflammation/pathology; Macrophages/metabolism; Macrophages/pathology; Male; Mice; Nitric Oxide/metabolism; Plant Preparations/chemistry; Rats; Tumor Necrosis Factor-alpha/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plants, Medicinal / Lipopolysaccharides / Cytochrome P-450 Enzyme System / Plant Preparations / Ether-A-Go-Go Potassium Channels / Cytochrome P-450 Enzyme Inhibitors Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Biomed Res Int Year: 2015 Document type: Article Affiliation country: India Country of publication: United States

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