Antineoplastic Agents/adverse effects; Enzyme Inhibitors/adverse effects; Hematopoiesis/drug effects; Megakaryocytes/drug effects; Niacin/metabolism; Nicotinamide Phosphoribosyltransferase/antagonists & inhibitors; Thrombocytopenia/chemically induced; Animals; Antineoplastic Agents/chemistry; Blood Platelets/drug effects; Blood Platelets/metabolism; Cells, Cultured; Colony-Forming Units Assay; Dietary Supplements; Drug Evaluation, Preclinical; Enzyme Inhibitors/chemistry; Food-Drug Interactions; Humans; Leukocytes, Mononuclear/cytology; Leukocytes, Mononuclear/drug effects; Leukocytes, Mononuclear/metabolism; Leukocytes, Mononuclear/pathology; Macaca fascicularis; Male; Megakaryocytes/cytology; Megakaryocytes/metabolism; Megakaryocytes/pathology; Mice; Molecular Structure; Niacin/therapeutic use; Nicotinamide Phosphoribosyltransferase/genetics; Nicotinamide Phosphoribosyltransferase/metabolism; Pentosyltransferases/genetics; Pentosyltransferases/metabolism; Rats, Sprague-Dawley; Thrombocytopenia/metabolism; Thrombocytopenia/prevention & control

Colony forming unit-megakaryocyte; hematotoxicity; platelet