Adjuvant S-1 chemotherapy after surgical resection for pancreatic adenocarcinoma.
Hepatogastroenterology
; 62(137): 169-74, 2015.
Article
in En
| MEDLINE
| ID: mdl-25911890
ABSTRACT
BACKGROUND/AIMS:
The aim of this study was determine the effectiveness of adjuvant S-1 chemotherapy for patients with resected pancreatic cancer.METHODOLOGY:
Patients with pancreatic carcinoma who underwent pancreatic resection without adjuvant S-1 chemotherapy (n = 11) or with adjuvant S-1 chemotherapy (n = 10) were included. S-1 was administered orally at a dose of 40 mg/m2 twice daily for 28 consecutive days followed by a 14-day pause. The cycle was repeated 4 times. Overall and disease-free survival curves were generated using the Kaplan-Meier method, and statistical differences between groups were analyzed using the log-rank test.RESULTS:
The disease-free survival and overall survival were longer among recipients of adjuvant S-1 chemotherapy than among those who received surgery alone (P < 0.05; 5-year disease-free survival rate, 30% versus 0%; 5-year overall survival rate, 65% vs 0%). Although dose reduction was needed in 2 patients because of grade 2 anorexia, only 1 patient with grade 2 hypoalbuminemia discontinued adjuvant chemotherapy because of long-term hospitalization.CONCLUSIONS:
S-1 administered as a single agent showed promise as an adjuvant chemotherapy for resected pancreatic cancer.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxonic Acid
/
Pancreatic Neoplasms
/
Adenocarcinoma
/
Tegafur
/
Pancreaticoduodenectomy
/
Antimetabolites, Antineoplastic
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Hepatogastroenterology
Year:
2015
Document type:
Article