Liver hydrolysate attenuates the sickness behavior induced by concanavalin A in mice.
J Pharmacol Sci
; 127(4): 489-92, 2015 Apr.
Article
in En
| MEDLINE
| ID: mdl-25913758
ABSTRACT
Liver hydrolysate (LH) is used as a pharmaceutical agent in Japan, to enhance liver function. However, the effects of LH on sickness behavior are unknown. This study investigated the effect of LH on sickness behaviors, such as concanavalin A (ConA)-induced reduction of locomotor activity. ConA treatment significantly decreased locomotor activity. The striatal tyrosine hydroxylase (TH) levels were also significantly decreased following ConA treatment. The decreased locomotor activity and TH levels were significantly reversed by LH treatment. LH may prove beneficial for preventing sickness behavior following ConA treatment, at least in part, by activating TH in the striatum.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protein Hydrolysates
/
Concanavalin A
/
Illness Behavior
/
Motor Disorders
/
Liver
/
Motor Activity
Limits:
Animals
Language:
En
Journal:
J Pharmacol Sci
Journal subject:
FARMACOLOGIA
Year:
2015
Document type:
Article