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Liver hydrolysate attenuates the sickness behavior induced by concanavalin A in mice.
Nakagawasai, Osamu; Yamada, Kotaro; Nemoto, Wataru; Sato, Shin; Ogata, Yoshiki; Miya, Kohei; Sakurai, Hidetomo; Tan-No, Koichi.
Affiliation
  • Nakagawasai O; Department of Pharmacology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan. Electronic address: osamun@tohoku-pharm.ac.jp.
  • Yamada K; Consumer Healthcare Products Development, Zeria Pharmaceutical Co., Ltd., Tokyo 103-8351, Japan.
  • Nemoto W; Department of Pharmacology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan.
  • Sato S; Department of Pharmacology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan.
  • Ogata Y; Department of Pharmacology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan.
  • Miya K; Department of Pharmacology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan.
  • Sakurai H; Consumer Healthcare Products Development, Zeria Pharmaceutical Co., Ltd., Tokyo 103-8351, Japan.
  • Tan-No K; Department of Pharmacology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan.
J Pharmacol Sci ; 127(4): 489-92, 2015 Apr.
Article in En | MEDLINE | ID: mdl-25913758
ABSTRACT
Liver hydrolysate (LH) is used as a pharmaceutical agent in Japan, to enhance liver function. However, the effects of LH on sickness behavior are unknown. This study investigated the effect of LH on sickness behaviors, such as concanavalin A (ConA)-induced reduction of locomotor activity. ConA treatment significantly decreased locomotor activity. The striatal tyrosine hydroxylase (TH) levels were also significantly decreased following ConA treatment. The decreased locomotor activity and TH levels were significantly reversed by LH treatment. LH may prove beneficial for preventing sickness behavior following ConA treatment, at least in part, by activating TH in the striatum.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Hydrolysates / Concanavalin A / Illness Behavior / Motor Disorders / Liver / Motor Activity Limits: Animals Language: En Journal: J Pharmacol Sci Journal subject: FARMACOLOGIA Year: 2015 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Hydrolysates / Concanavalin A / Illness Behavior / Motor Disorders / Liver / Motor Activity Limits: Animals Language: En Journal: J Pharmacol Sci Journal subject: FARMACOLOGIA Year: 2015 Document type: Article