MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and -independent mechanisms.

Amankwatia, E B; Chakravarty, P; Carey, F A; Weidlich, S; Steele, R J C; Munro, A J; Wolf, C R; Smith, G

Amankwatia, E B; Chakravarty, P; Carey, F A; Weidlich, S; Steele, R J C; Munro, A J; Wolf, C R; Smith, G.

Affiliation

Amankwatia EB; Division of Cancer Research, Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
Chakravarty P; Bioinformatics and Biostatistics Service, Cancer Research UK, 44 Lincolns Inn Fields, London WC2A 3PX, UK.
Carey FA; Department of Pathology, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
Weidlich S; Division of Cancer Research, Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
Steele RJ; Division of Cancer Research, Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
Munro AJ; Division of Cancer Research, Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
Wolf CR; 1] Division of Cancer Research, Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK [2] CRUK Molecular Pharmacology Unit, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
Smith G; Division of Cancer Research, Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.

Br J Cancer ; 112(9): 1480-90, 2015 Apr 28.

Article in En | MEDLINE | ID: mdl-25919696

Subject(s)

Adenoma/pathology; Colorectal Neoplasms/pathology; Drug Resistance, Neoplasm/genetics; Fluorouracil/pharmacology; Liver Neoplasms/secondary; MicroRNAs/genetics; Proto-Oncogene Proteins/genetics; ras Proteins/genetics; Adenoma/drug therapy; Adenoma/genetics; Animals; Antimetabolites, Antineoplastic/pharmacology; Apoptosis/drug effects; Cell Proliferation/drug effects; Colorectal Neoplasms/drug therapy; Colorectal Neoplasms/genetics; Disease Progression; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms/drug therapy; Liver Neoplasms/genetics; Lymphatic Metastasis; Mice; Mutation/genetics; NIH 3T3 Cells; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Proto-Oncogene Proteins p21(ras); RNA, Messenger/genetics; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tumor Cells, Cultured

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Adenoma / Proto-Oncogene Proteins / Ras Proteins / Drug Resistance, Neoplasm / MicroRNAs / Fluorouracil / Liver Neoplasms Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Br J Cancer Year: 2015 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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