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Zeb family members and boundary cap cells underlie developmental plasticity of sensory nociceptive neurons.
Ohayon, David; Ventéo, Stéphanie; Sonrier, Corinne; Lafon, Pierre-André; Garcès, Alain; Valmier, Jean; Rivat, Cyril; Topilko, Piotr; Carroll, Patrick; Pattyn, Alexandre.
Affiliation
  • Ohayon D; INSERM U1051, Institut des Neurosciences de Montpellier, 34091 Montpellier, France; Université de Toulouse, Centre de Biologie du Développement, UMR5547 CNRS, 31062 Toulouse, France.
  • Ventéo S; INSERM U1051, Institut des Neurosciences de Montpellier, 34091 Montpellier, France.
  • Sonrier C; INSERM U1051, Institut des Neurosciences de Montpellier, 34091 Montpellier, France.
  • Lafon PA; INSERM U1051, Institut des Neurosciences de Montpellier, 34091 Montpellier, France.
  • Garcès A; INSERM U1051, Institut des Neurosciences de Montpellier, 34091 Montpellier, France.
  • Valmier J; INSERM U1051, Institut des Neurosciences de Montpellier, 34091 Montpellier, France; Université Montpellier 2, 34091 Montpellier, France.
  • Rivat C; INSERM U1051, Institut des Neurosciences de Montpellier, 34091 Montpellier, France; Université Montpellier 2, 34091 Montpellier, France.
  • Topilko P; INSERM U1024, Ecole Normale Supérieure, 75230 Paris, France.
  • Carroll P; INSERM U1051, Institut des Neurosciences de Montpellier, 34091 Montpellier, France.
  • Pattyn A; INSERM U1051, Institut des Neurosciences de Montpellier, 34091 Montpellier, France. Electronic address: alexandre.pattyn@inserm.fr.
Dev Cell ; 33(3): 343-50, 2015 May 04.
Article in En | MEDLINE | ID: mdl-25942625
Dorsal root ganglia (DRG) sensory neurons arise from heterogeneous precursors that differentiate in two neurogenic waves, respectively controlled by Neurog2 and Neurog1. We show here that transgenic mice expressing a Zeb1/2 dominant-negative form (DBZEB) exhibit reduced numbers of nociceptors and altered pain sensitivity. This reflects an early impairment of Neurog1-dependent neurogenesis due to the depletion of specific sensory precursor pools, which is slightly later partially compensated by the contribution of boundary cap cells (BCCs). Indeed, combined DBZEB expression and genetic BCCs ablation entirely deplete second wave precursors and, in turn, nociceptors, thus recapitulating the Neurog1(-/-) neuronal phenotype. Altogether, our results uncover roles for Zeb family members in the developing DRGs; they show that the Neurog1-dependent sensory neurogenesis can be functionally partitioned in two successive phases; and finally, they illustrate plasticity in the developing peripheral somatosensory system supported by the BCCs, thereby providing a rationale for sensory precursor diversity.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Nociceptors / Homeodomain Proteins / Kruppel-Like Transcription Factors / Neuronal Plasticity Limits: Animals Language: En Journal: Dev Cell Journal subject: EMBRIOLOGIA Year: 2015 Document type: Article Affiliation country: France Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Nociceptors / Homeodomain Proteins / Kruppel-Like Transcription Factors / Neuronal Plasticity Limits: Animals Language: En Journal: Dev Cell Journal subject: EMBRIOLOGIA Year: 2015 Document type: Article Affiliation country: France Country of publication: United States