Mutation; Nephrotic Syndrome; Podocytes; Proteinuria; Tumor Suppressor Proteins; Adaptor Proteins, Signal Transducing; Animals; Cell Line; Cytoskeletal Proteins; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila melanogaster; Female; Gene Knockdown Techniques; Humans; Male; Microfilament Proteins/genetics; Microfilament Proteins/metabolism; Nephrotic Syndrome/genetics; Nephrotic Syndrome/metabolism; Nephrotic Syndrome/pathology; Podocytes/metabolism; Podocytes/pathology; Proteinuria/genetics; Proteinuria/metabolism; Proteinuria/pathology; Rats; Tumor Suppressor Proteins/deficiency; Tumor Suppressor Proteins/metabolism; Zebrafish/genetics; Zebrafish/metabolism; Zebrafish Proteins/genetics; Zebrafish Proteins/metabolism