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Effects of bisphenol A on decreasing the percentage and promoting the growth of stem cell-like cells from SK-N-SH human neuroblastoma cells.
Zheng, J C; Qi, S Q; Yang, L; Ma, Y Y; Dong, K R; Zhu, H T; Yang, S B; Xu, T; Zheng, S; Xiao, X M.
Affiliation
  • Zheng JC; Department of Pediatric Surgery, Children's Hospital, Fudan University, Shanghai, China.
  • Qi SQ; Department of Pediatric Surgery, Anhui Provincial Children's Hospital, Hefei, China.
  • Yang L; Department of Pediatric Surgery, Children's Hospital, Fudan University, Shanghai, China.
  • Ma YY; Department of Pediatric Surgery, Children's Hospital, Fudan University, Shanghai, China.
  • Dong KR; Department of Pediatric Surgery, Children's Hospital, Fudan University, Shanghai, China.
  • Zhu HT; Department of Pediatric Surgery, Children's Hospital, Fudan University, Shanghai, China.
  • Yang SB; Department of Pediatric Surgery, Children's Hospital, Fudan University, Shanghai, China.
  • Xu T; Department of Pediatric Surgery, Children's Hospital, Fudan University, Shanghai, China.
  • Zheng S; Department of Pediatric Surgery, Children's Hospital, Fudan University, Shanghai, China.
  • Xiao XM; Department of Pediatric Surgery, Children's Hospital, Fudan University, Shanghai, China xxianmin@126.com.
Genet Mol Res ; 14(2): 2986-93, 2015 Apr 10.
Article in En | MEDLINE | ID: mdl-25966062
ABSTRACT
Bisphenol A (BPA) is an industrial contaminant and is reported to be a risk factor associated with the development of tumors. In our previous studies, we have shown that BPA promoted the growth of SK-N-SH human neuroblastoma cells and increased their invasion and metastasis. In this study, we further investigated the effects of BPA and 17ß-estradiol (E2) on the stem cell-like cells from SK-N-SH cells. Detection of stem cell markers, proliferation assay, and clonogenic analysis showed that the side-population (SP) of SK-N-SH cells had properties similar to those of stem cells. BPA or E2 exposure decreased the percentage of SP cells and the expression of stem cell-marker proteins. BPA and E2 promoted the growth of non-SP cells to a greater extent than of SP cells; in addition, they significantly increased the growth of SP cells. Thus, BPA has effects on stem cell-like cells, which induce tumor formation, and thus, BPA is an environmental factor that plays an important role in the development of neuroblastoma.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenols / Neoplastic Stem Cells / Benzhydryl Compounds / Neuroblastoma Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Genet Mol Res Journal subject: BIOLOGIA MOLECULAR / GENETICA Year: 2015 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenols / Neoplastic Stem Cells / Benzhydryl Compounds / Neuroblastoma Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Genet Mol Res Journal subject: BIOLOGIA MOLECULAR / GENETICA Year: 2015 Document type: Article Affiliation country: China