Studies of MR 889, a new synthetic proteinase inhibitor.
Biochem Biophys Res Commun
; 165(2): 568-73, 1989 Dec 15.
Article
in En
| MEDLINE
| ID: mdl-2597145
ABSTRACT
We investigated the proteinase inhibitory activity of MR 889, a thiolactic acid derivative. It is able to in vitro inhibit at low concentration (10(-5),10(-6)M) the activity of porcine pancreatic elastase, human neutrophil elastase and bovine chymotrypsin. In addition, MR 889 is able to inhibit the residual activity of alpha 2-macroglobulin-trapped human neutrophil elastase, paralleling the efficacy of phenylmethylsufonylfluoride. Finally, MR 889 has been shown to in vitro reduce the burden of elastase- and chymotrypsin-like activity found in sputum sol-phases of patients admitted for chronic bronchitis exacerbation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protease Inhibitors
/
Thiophenes
Limits:
Humans
Language:
En
Journal:
Biochem Biophys Res Commun
Year:
1989
Document type:
Article
Affiliation country:
Italy