Effect of Water T2 Shortening in the Quantification of in-vitro Proton MR Spectroscopy.
J Neuroimaging
; 26(1): 58-61, 2016.
Article
in En
| MEDLINE
| ID: mdl-25996684
ABSTRACT
PURPOSE:
This work studies the relationship between in-vitro Proton Magnetic Resonance Spectroscopy metabolite quantification and water T2 decay. MATERIALS ANDMETHODS:
An in-vitro correspondence is established between the iron accumulation and the shortening of water T2 relaxation times using seven spherical phantoms, 6 of them were doped with an increasing concentration of iron metal nanoparticles solution. This is later proposed as a source of error during the LCModel metabolite quantification of either absolute concentrations or ratios.RESULTS:
The Pearson's correlation coefficient between water T2 values against absolute metabolite concentrations was on average [r] = 0.97 and on average [r] = 0.85 for metabolite ratios.CONCLUSION:
These results suggest that the shortening of T2 values should be taken into account when performing metabolite quantification. Also, the need of demonstrated similar results in in-vivo studies, since the presence of iron deposits or other factors affecting the water T2 decay measurements could explain part of the inter-subject variability in the metabolite concentration and ratio quantification.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Proton Magnetic Resonance Spectroscopy
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
J Neuroimaging
Journal subject:
DIAGNOSTICO POR IMAGEM
/
NEUROLOGIA
Year:
2016
Document type:
Article
Affiliation country:
Spain