Leptin: From structural insights to the design of antagonists.
Life Sci
; 140: 49-56, 2015 Nov 01.
Article
in En
| MEDLINE
| ID: mdl-25998027
ABSTRACT
After its discovery in 1994, it soon became clear that leptin acts as an adipocyte-derived hormone with a central role in the control of body weight and energy homeostasis. However, a growing body of evidence has revealed that leptin is a pleiotropic cytokine with activities on many peripheral cell types. Inappropriate leptin signaling can promote autoimmunity, certain cardiovascular diseases, elevated blood pressure and cancer, which makes leptin and the leptin receptor interesting targets for antagonism. Profound insights in the leptin receptor (LR) activation mechanisms are a prerequisite for the rational design of these antagonists. In this review, we focus on the molecular mechanisms underlying leptin receptor activation and signaling. We also discuss the current strategies to interfere with leptin signaling and their therapeutic potential.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Leptin
/
Receptors, Leptin
Limits:
Humans
Language:
En
Journal:
Life Sci
Year:
2015
Document type:
Article
Affiliation country:
Belgium
Publication country:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS