Progression of activity and structural changes in the anterior cingulate cortex during remote memory formation.
Neurobiol Learn Mem
; 123: 67-71, 2015 Sep.
Article
in En
| MEDLINE
| ID: mdl-26001597
ABSTRACT
The progression of activity and structural changes in the anterior cingulate cortex during remote contextual fear memory formation was measured by imaging c-fos expression and dendritic spines following retrieval tests administered at six post-training time points (days 1, 5, 7, 14, 21, 36). Here we report that conditioned mice exhibit robust freezing at each time point. C-fos expression starts to augment on day 5, showing a monotonic increase over the successive time points, and then stabilized in relation to the higher freezing scores. The first significant increase in mean spine density emerges on day 7. By day 14, the net number of spines remained stable, yet the distribution of single neuron spine density becomes progressively more homogeneous. Our findings reveal that activity changes precede structural remodeling of neurons in the neocortex while remodeling coherence develops gradually in cortical neuron ensembles.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Behavior, Animal
/
Proto-Oncogene Proteins c-fos
/
Dendritic Spines
/
Memory, Long-Term
/
Gyrus Cinguli
Limits:
Animals
Language:
En
Journal:
Neurobiol Learn Mem
Journal subject:
BIOLOGIA
/
CIENCIAS DO COMPORTAMENTO
/
NEUROLOGIA
Year:
2015
Document type:
Article
Affiliation country:
United States