[Role of transcription factors in transdifferentiation of the gastric mucosa].

Vernygorodskyi, S V; Degtiariova, L V; Iatsyna, O I; Blume, Ya B; Yemets, A I

Vernygorodskyi, S V; Degtiariova, L V; Iatsyna, O I; Blume, Ya B; Yemets, A I.

Tsitol Genet ; 49(2): 42-7, 2015.

Article in Uk | MEDLINE | ID: mdl-26030973

ABSTRACT

The analysis of intestinal differentiation transcription factor CDX2 in the gastric mucosa biopsies has been carried out. It was established that CDX2 by itself promoter activation pathway can obtain intestinal phenotype for gastric mucosa cells. The loss of CDX2 expression in the nuclei of metaplastic epithelium may serve as a predictor of gastric mucosa malignization.

Subject(s)

Cell Transformation, Neoplastic/genetics; Gastric Mucosa/pathology; Gene Expression Regulation, Neoplastic; Helicobacter Infections/genetics; Homeodomain Proteins/genetics; Stomach Neoplasms/genetics; Biomarkers/metabolism; CDX2 Transcription Factor; Cell Nucleus/genetics; Cell Nucleus/metabolism; Cell Transdifferentiation/genetics; Cell Transformation, Neoplastic/metabolism; Cell Transformation, Neoplastic/pathology; Epithelial Cells/metabolism; Epithelial Cells/pathology; Female; Gastric Mucosa/metabolism; Helicobacter Infections/metabolism; Helicobacter Infections/microbiology; Helicobacter Infections/pathology; Helicobacter pylori/physiology; Homeodomain Proteins/metabolism; Humans; Intestinal Mucosa/metabolism; Intestinal Mucosa/pathology; Male; Metaplasia/genetics; Metaplasia/metabolism; Metaplasia/pathology; Middle Aged; Phenotype; Promoter Regions, Genetic; Stomach Neoplasms/metabolism; Stomach Neoplasms/pathology

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Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Gene Expression Regulation, Neoplastic / Cell Transformation, Neoplastic / Helicobacter Infections / Homeodomain Proteins / Gastric Mucosa Type of study: Prognostic_studies Limits: Female / Humans / Male / Middle aged Language: Uk Journal: Tsitol Genet Year: 2015 Document type: Article Country of publication: Ukraine

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