The impact of vitamin D3 supplementation on muscle function among HIV-infected children and young adults: a randomized controlled trial.
J Musculoskelet Neuronal Interact
; 15(2): 145-53, 2015 Jun.
Article
in En
| MEDLINE
| ID: mdl-26032206
ABSTRACT
OBJECTIVES:
We tested the hypothesis that daily vitD3 supplementation increases neuromuscular motor skills, jump power, jump energy, muscular force, and muscular strength.METHODS:
This was a secondary analysis of a randomized controlled trial of 12-months of oral 7,000 IU/day vitD3 supplementation or placebo among 56 persons living with HIV aged 9-25 years. Neuromuscular motor skills were quantified using the Bruininks-Oseretsky Test of Motor Proficiency. Power was quantified using peak jump power, and energy was quantified using peak jump height. Muscular force was quantified using isometric ankle plantar- and dorsiflexion, isokinetic knee flexion and extension. Muscular strength was quantified using isometric handgrip strength.RESULTS:
After 12-months, serum 25-hydroxyvitamin D [25(OH)D] was higher with supplementation versus placebo (ß=12.1 ng/mL; P<0.001). In intention-to-treat analyses, supplementation improved neuromuscular motor skills versus placebo (ß=1.14; P=0.041). We observed no effect of supplementation on jump power, jump energy, muscular force, or muscular strength outcomes versus placebo.CONCLUSIONS:
Among HIV-infected children and young adults supplementation with daily high-dose vitD3 increased concentration of serum 25(OH)D and improved neuromuscular motor skills versus placebo.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vitamins
/
HIV Infections
/
Cholecalciferol
/
Muscle, Skeletal
/
Dietary Supplements
Type of study:
Clinical_trials
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
En
Journal:
J Musculoskelet Neuronal Interact
Journal subject:
FISIOLOGIA
/
NEUROLOGIA
/
ORTOPEDIA
Year:
2015
Document type:
Article