Structure-based discovery of an immunomodulatory inhibitor of TLR1-TLR2 heterodimerization from a natural product-like database.

Zhong, Zhangfeng; Liu, Li-Juan; Dong, Zhi-Qiang; Lu, Lihua; Wang, Modi; Leung, Chung-Hang; Ma, Dik-Lung; Wang, Yitao

Zhong, Zhangfeng; Liu, Li-Juan; Dong, Zhi-Qiang; Lu, Lihua; Wang, Modi; Leung, Chung-Hang; Ma, Dik-Lung; Wang, Yitao.

Affiliation

Zhong Z; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China. YTWang@umac.mo duncanleung@umac.mo.

Chem Commun (Camb) ; 51(56): 11178-81, 2015 Jun 30.

Article in En | MEDLINE | ID: mdl-26051605

Subject(s)

Biological Products/pharmacology; Immunologic Factors/pharmacology; Toll-Like Receptor 1/antagonists & inhibitors; Toll-Like Receptor 2/antagonists & inhibitors; Biological Products/chemistry; Databases, Chemical; Dimerization; Humans; Immunologic Factors/chemistry; Macrophages/drug effects; Molecular Docking Simulation; Molecular Structure

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biological Products / Toll-Like Receptor 1 / Toll-Like Receptor 2 / Immunologic Factors Type of study: Prognostic_studies Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2015 Document type: Article Country of publication: United kingdom

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