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Therapeutic effects of human urocortin-1, -2 and -3 in intracerebral hemorrhage of rats.
Liew, Hock-Kean; Huang, Li-Chuan; Yang, Hui-I; Peng, Hsiao-Fen; Li, Kuo-Wei; Tsai, Andy Po-Yi; Chen, Shin-Yuan; Kuo, Jon-Son; Pang, Cheng-Yoong.
Affiliation
  • Liew HK; Department of Medical Research, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, ROC.
  • Huang LC; Department of Radiology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, ROC; Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan, ROC.
  • Yang HI; Department of Medical Research, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, ROC.
  • Peng HF; Department of Medical Research, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, ROC.
  • Li KW; Department of Medical Research, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, ROC; Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan, ROC.
  • Tsai AP; Institute of Pharmacology and Toxicology, Tzu Chi University, Hualien, Taiwan, ROC.
  • Chen SY; Department of Neurosurgery, Buddhist Tzu Chi General Hospital, Tzu Chi University, Hualien, Taiwan, ROC; Neuro-Medical Scientific Center, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, ROC.
  • Kuo JS; Institute of Pharmacology and Toxicology, Tzu Chi University, Hualien, Taiwan, ROC; Neuro-Medical Scientific Center, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, ROC.
  • Pang CY; Department of Medical Research, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, ROC; Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan, ROC. Electronic address: cypang@mail.tcu.edu.tw.
Neuropeptides ; 52: 89-96, 2015 Aug.
Article in En | MEDLINE | ID: mdl-26055808
ABSTRACT
Urocortin exerts neuroprotective effects in intracerebral hemorrhage (ICH) of rats. For pre-clinical trial, we intended to study the neuroprotective efficacy of human UCN (hUCN)-1, -2 and -3 in treating ICH rats. ICH was induced by infusing bacterial collagenase VII (0.23 U in sterile saline) to the striatum. The hUCN-1, -2, and -3 were administrated (2.5µg/kg, i.p.) at 1h after ICH insult, respectively. Neurological deficits were evaluated by modified Neurological Severity Scores. Brain edema and hematoma expansion was evaluated by coronal T2-WI and DWI magnetic resonance imaging on 1, 3, 6, 24, and 56h after ICH insult. Blood-brain barrier permeability was evaluated by Evans blue assay on day 3 after ICH. Brain lesion volume was evaluated by morphormetric measurement on day 7 after ICH. Our results demonstrated that the hUCN-1 significantly reduced hematoma, blood-brain barrier disruption and neurological deficits on day 3, and brain lesion volume on day 7 after ICH insult. The prediction of secondary structure of the hUCNs clarifies that the percentage of alpha-helix, random coil and extended strand between rat-UCN (rUCN)-1 and hUCN-1 are the same. The structure similarity between human- and rat-UCN-1 may be one of the reasons that both can exert similar therapeutic potential in ICH rats.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Corticotropin-Releasing Hormone / Cerebral Hemorrhage / Neuroprotective Agents / Corpus Striatum / Urocortins Type of study: Clinical_trials / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Neuropeptides Year: 2015 Document type: Article Publication country: HOLANDA / HOLLAND / NETHERLANDS / NL / PAISES BAJOS / THE NETHERLANDS
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Corticotropin-Releasing Hormone / Cerebral Hemorrhage / Neuroprotective Agents / Corpus Striatum / Urocortins Type of study: Clinical_trials / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Neuropeptides Year: 2015 Document type: Article Publication country: HOLANDA / HOLLAND / NETHERLANDS / NL / PAISES BAJOS / THE NETHERLANDS