Mitochondria-Targeted Plastoquinone Antioxidant SkQR1 Has Positive Effect on Memory of Rats.
Biochemistry (Mosc)
; 80(5): 592-5, 2015 May.
Article
in En
| MEDLINE
| ID: mdl-26071778
ABSTRACT
A single intraperitoneal injection to rats of the mitochondria-targeted plastoquinone antioxidant SkQR1 at dose 1 µmol/kg significantly improved reproduction by the rats of the passive avoidance conditional reflex. In vitro experiments on hippocampal slices showed that a single intraperitoneal injection of SkQR1 24 h before the preparation of the slice significantly increases the synaptic transmission efficiency of the pyramidal neurons of the CA1 field. The findings indicate that SkQR1 has a positive effect on memory processes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rhodamines
/
Plastoquinone
/
Pyramidal Cells
/
Memory
/
Mitochondria
Limits:
Animals
Language:
En
Journal:
Biochemistry (Mosc)
Year:
2015
Document type:
Article
Affiliation country:
RUSSIA