In vivo kinetic approach reveals slow SOD1 turnover in the CNS.

Crisp, Matthew J; Mawuenyega, Kwasi G; Patterson, Bruce W; Reddy, Naveen C; Chott, Robert; Self, Wade K; Weihl, Conrad C; Jockel-Balsarotti, Jennifer; Varadhachary, Arun S; Bucelli, Robert C; Yarasheski, Kevin E; Bateman, Randall J; Miller, Timothy M

Crisp, Matthew J; Mawuenyega, Kwasi G; Patterson, Bruce W; Reddy, Naveen C; Chott, Robert; Self, Wade K; Weihl, Conrad C; Jockel-Balsarotti, Jennifer; Varadhachary, Arun S; Bucelli, Robert C; Yarasheski, Kevin E; Bateman, Randall J; Miller, Timothy M.

J Clin Invest ; 125(7): 2772-80, 2015 Jul 01.

Article in En | MEDLINE | ID: mdl-26075819

Subject(s)

Central Nervous System/enzymology; Superoxide Dismutase/metabolism; Amino Acid Sequence; Amino Acid Substitution; Amyotrophic Lateral Sclerosis/cerebrospinal fluid; Amyotrophic Lateral Sclerosis/enzymology; Amyotrophic Lateral Sclerosis/genetics; Animals; Carbon Isotopes; Disease Models, Animal; Female; HEK293 Cells; Humans; Isotope Labeling; Kinetics; Male; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutant Proteins/cerebrospinal fluid; Mutant Proteins/genetics; Mutant Proteins/metabolism; Rats; Rats, Transgenic; Recombinant Proteins/cerebrospinal fluid; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Superoxide Dismutase/cerebrospinal fluid; Superoxide Dismutase/genetics; Superoxide Dismutase-1; Tandem Mass Spectrometry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Superoxide Dismutase / Central Nervous System Limits: Animals / Female / Humans / Male Language: En Journal: J Clin Invest Year: 2015 Document type: Article Country of publication: United States

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