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Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.
Miller, Bryan W; Morton, Jennifer P; Pinese, Mark; Saturno, Grazia; Jamieson, Nigel B; McGhee, Ewan; Timpson, Paul; Leach, Joshua; McGarry, Lynn; Shanks, Emma; Bailey, Peter; Chang, David; Oien, Karin; Karim, Saadia; Au, Amy; Steele, Colin; Carter, Christopher Ross; McKay, Colin; Anderson, Kurt; Evans, Thomas R Jeffry; Marais, Richard; Springer, Caroline; Biankin, Andrew; Erler, Janine T; Sansom, Owen J.
Affiliation
  • Miller BW; Cancer Research UK Beatson Institute Garscube Estate, Glasgow, UK.
  • Morton JP; Cancer Research UK Beatson Institute Garscube Estate, Glasgow, UK.
  • Pinese M; The Garvan Institute of Medical Research, Sydney, NSW, Australia.
  • Saturno G; Cancer Research UK Manchester Institute, Withington Manchester, UK.
  • Jamieson NB; West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, UK.
  • McGhee E; Cancer Research UK Beatson Institute Garscube Estate, Glasgow, UK.
  • Timpson P; The Garvan Institute of Medical Research, Sydney, NSW, Australia.
  • Leach J; Cancer Research UK Beatson Institute Garscube Estate, Glasgow, UK.
  • McGarry L; Cancer Research UK Beatson Institute Garscube Estate, Glasgow, UK.
  • Shanks E; Cancer Research UK Beatson Institute Garscube Estate, Glasgow, UK.
  • Bailey P; Institute of Cancer Sciences University of Glasgow Garscube Estate, Glasgow, UK.
  • Chang D; Institute of Cancer Sciences University of Glasgow Garscube Estate, Glasgow, UK.
  • Oien K; Institute of Cancer Sciences University of Glasgow Garscube Estate, Glasgow, UK.
  • Karim S; Cancer Research UK Beatson Institute Garscube Estate, Glasgow, UK.
  • Au A; Cancer Research UK Beatson Institute Garscube Estate, Glasgow, UK.
  • Steele C; Cancer Research UK Beatson Institute Garscube Estate, Glasgow, UK.
  • Carter CR; West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, UK.
  • McKay C; West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, UK.
  • Anderson K; Cancer Research UK Beatson Institute Garscube Estate, Glasgow, UK.
  • Evans TR; Cancer Research UK Beatson Institute Garscube Estate, Glasgow, UK Institute of Cancer Sciences University of Glasgow Garscube Estate, Glasgow, UK.
  • Marais R; Cancer Research UK Manchester Institute, Withington Manchester, UK.
  • Springer C; Institute of Cancer Research, London, UK.
  • Biankin A; Institute of Cancer Sciences University of Glasgow Garscube Estate, Glasgow, UK.
  • Erler JT; Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Copenhagen (UCPH), Denmark janine.erler@bric.ku.dk o.sansom@beatson.gla.ac.uk.
  • Sansom OJ; Cancer Research UK Beatson Institute Garscube Estate, Glasgow, UK janine.erler@bric.ku.dk o.sansom@beatson.gla.ac.uk.
EMBO Mol Med ; 7(8): 1063-76, 2015 Aug.
Article in En | MEDLINE | ID: mdl-26077591
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Carcinoma, Pancreatic Ductal / Protein-Lysine 6-Oxidase Limits: Animals / Humans Language: En Journal: EMBO Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2015 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Carcinoma, Pancreatic Ductal / Protein-Lysine 6-Oxidase Limits: Animals / Humans Language: En Journal: EMBO Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2015 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom