Structure-Activity Relationships of 1,2-Disubstituted Benzimidazoles: Selective Inhibition of Heme Oxygenase-2 Activity.

Kong, Xianqi; Vukomanovic, Dragic; Nakatsu, Kanji; Szarek, Walter A

Kong, Xianqi; Vukomanovic, Dragic; Nakatsu, Kanji; Szarek, Walter A.

Affiliation

Kong X; Department of Chemistry, Queen's University, Kingston, ON K7Lâ3N6 (Canada).
Vukomanovic D; Department of Biomedical & Molecular Sciences, Queen's University, Kingston, ON K7Lâ3N6 (Canada).
Nakatsu K; Department of Biomedical & Molecular Sciences, Queen's University, Kingston, ON K7Lâ3N6 (Canada).
Szarek WA; Department of Chemistry, Queen's University, Kingston, ON K7Lâ3N6 (Canada). walter.szarek@chem.queensu.ca.

ChemMedChem ; 10(8): 1435-41, 2015 Aug.

Article in En | MEDLINE | ID: mdl-26083133

Subject(s)

Benzimidazoles/chemistry; Heme Oxygenase (Decyclizing)/antagonists & inhibitors; Animals; Benzimidazoles/chemical synthesis; Benzimidazoles/metabolism; Brain/enzymology; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/metabolism; Heme Oxygenase (Decyclizing)/metabolism; Heme Oxygenase-1/antagonists & inhibitors; Heme Oxygenase-1/metabolism; Protein Binding; Rats; Spleen/enzymology; Structure-Activity Relationship

Key words

1,2-disubstituted 1H-benzimidazoles; heme oxygenases; inhibitors; structure-activity relationships

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzimidazoles / Heme Oxygenase (Decyclizing) Limits: Animals Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2015 Document type: Article Country of publication: Germany

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