Pioglitazone in adult rats reverses immediate postnatal overfeeding-induced metabolic, hormonal, and inflammatory alterations.

Boullu-Ciocca, S; Tassistro, V; Dutour, A; Grino, M

Boullu-Ciocca, S; Tassistro, V; Dutour, A; Grino, M.

Affiliation

Boullu-Ciocca S; Aix-Marseille Univ, Faculté de Médecine, 13385, Marseille, France.
Tassistro V; Aix-Marseille Univ, Faculté de Médecine, 13385, Marseille, France.
Dutour A; Inserm, UMR1062, "Nutrition, Obesity and Risk of Thrombosis", 13385, Marseille, France.
Grino M; INRA, UMR1260, 13385, Marseille, France.

Endocrine ; 50(3): 608-19, 2015 Dec.

Article in En | MEDLINE | ID: mdl-26084260

Subject(s)

Hypoglycemic Agents/therapeutic use; Obesity/prevention & control; Thiazolidinediones/therapeutic use; 11-beta-Hydroxysteroid Dehydrogenase Type 1/metabolism; Adiponectin/blood; Adipose Tissue/drug effects; Adipose Tissue/metabolism; Animals; Drug Evaluation, Preclinical; Female; Hyperphagia/complications; Hypoglycemic Agents/pharmacology; In Vitro Techniques; Inflammation/etiology; Inflammation/prevention & control; Male; Obesity/etiology; Pioglitazone; Plasminogen Activator Inhibitor 1/metabolism; Random Allocation; Rats, Wistar; Receptors, Glucocorticoid/metabolism; Thiazolidinediones/pharmacology; Weight Gain/drug effects

Key words

11ß-Hydroxysteroid dehydrogenase type 1; Glucocorticoid receptor; Inflammation; Metabolic syndrome; Pioglitazone; Postnatal programing

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiazolidinediones / Hypoglycemic Agents / Obesity Type of study: Etiology_studies Limits: Animals Language: En Journal: Endocrine Journal subject: ENDOCRINOLOGIA Year: 2015 Document type: Article Affiliation country: France

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